CNS Noradrenaline and Pain
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چکیده
IAntinociceptive at the spinal level Adding NA is antinociceptive The story gets complicated because NA both inhibits and facilitates spinal nociceptive reflexes Spinal NA increases with acute and chronic nociceptive stimuli. NA tonically induces antinociception NA spinal denervation produces hyper and hypoalgesia NA spinal denervation retards the appearance of autotomy and neuropathic pain NA phasically induces antinociception Effect of removing NA at the spinal level on pain behavior Removing NA produces hypersensitivity of the noradrenergic receptors NA spinal denervation blocks serotoninergic induced antinociception
منابع مشابه
Alterations of noradrenalin and one of its metabolites in the Locus Coeroleus nucleus in formalin induced pain in anesthetized rat
Introduction: Pain as a complex process in central nervous system (CNS) has been studied by many researchers. Pain is controlled by several CNS pathways, one of the most important of which, is the descending noradrenergic system. This system begins from locus coeruleus (LC) nucleus in pons and ends in the spinal cord. In this research, the effect of pain induced by formalin was studied. Met...
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